Description

Angiotensin II, Sar(1)-Val(5)-Ile(8)- is a potent, synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, designed for enhanced stability and research utility. This modified sequence is critical for investigating the renin-angiotensin system (RAS), a key regulator of blood pressure, fluid balance, and cardiovascular function. It serves as an indispensable tool for pharmaceutical R&D, biochemical research, and diagnostic assay development, enabling precise study of receptor interactions and pathway mechanisms.

Application

• Biomedical Research: Fundamental studies on the physiology and pharmacology of the renin-angiotensin system (RAS).
• Drug Discovery & Development: Screening and characterization of novel angiotensin receptor blockers (ARBs) and related therapeutics.
• Receptor Binding Assays: Used as a labeled or unlabeled ligand to study AT1 and AT2 receptor affinity, selectivity, and signaling.
• Diagnostic Kit Manufacturing: A key component in the production of immunoassay kits for measuring angiotensin peptides or related biomarkers.
• Academic & Institutional Research: Investigating cardiovascular diseases, kidney function, and hormonal regulation in laboratory settings.
• Peptide Chemistry Reference Standard: Serves as a high-purity benchmark for analytical method development and quality control of peptide-based products.

Basic Information

Product Name	Angiotensin II, Sar(1)-Val(5)-Ile(8)-
CAS No.	51274-63-6
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Sar¹,Val⁵,Ile⁸]-Angiotensin II; Saralasin Acetate; Sarcosine¹,Valine⁵,Isoleucine⁸-Angiotensin II; 1-Sar-8-Ile-Angiotensin II; NSC-177982; Angiotensin II antagonist; Sar¹-Val⁵-Ile⁸-AII; Saralasin
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Val(5)-Ile(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.