Description

Angiotensin II, Sar(1)-Val(5)- is a potent synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at the 1 and 5 positions. This compound is of significant value in cardiovascular and renal research as a selective agonist for the AT1 receptor subtype, providing a critical tool for studying hypertension, heart failure, and related signaling pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in the development of novel therapeutic agents targeting the renin-angiotensin system.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating the physiological and pathological roles of the renin-angiotensin-aldosterone system (RAAS).
• Drug Discovery & Development: Serves as a key biochemical tool for screening and validating potential AT1 receptor antagonists and modulators in high-throughput assays.
• Cardiovascular Studies: Employed in in vitro and in vivo models to induce vasoconstriction and study mechanisms of hypertension, vascular remodeling, and cardiac hypertrophy.
• Renal Function Research: Applied in experiments to examine effects on renal blood flow, glomerular filtration rate, and sodium reabsorption.
• Cell Signaling Pathways: Utilized to activate AT1 receptor-mediated intracellular signaling cascades, such as those involving IP3, calcium mobilization, and MAP kinases.
• Biochemical Assay Standard: Acts as a calibrated standard in radioimmunoassays (RIA) and enzyme-linked immunosorbent assays (ELISA) for quantifying Angiotensin II levels.

Basic Information

Product Name	Angiotensin II, Sar(1)-Val(5)-
CAS No.	51274-62-5
Molecular Formula	C49H69N13O11
Molecular Weight	1016.2 g/mol
Synonyms	Sar(1)-Val(5)-Angiotensin II; [Sar1,Val5]-Angiotensin II; [Sar1,Val5]Ang II; Saralasin Acetate (component); Angiotensin II (1-8) heptapeptide, 1-sarcosine-5-valine-; AT1 Receptor Agonist; H-Sar-Arg-Val-Tyr-Val-His-Pro-Phe-OH; Sarcosyl1,Valine5-angiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Val(5)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific purity requirements (>95%, >98%, etc.) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80% (by AAA)
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.