Description

Substance P Fragment 3-11 Acetate is a synthetic peptide fragment of the neuropeptide Substance P, specifically the sequence from amino acids 3 to 11, with an acetate salt form. This compound is a critical research tool for studying the structure-activity relationships and biological functions of Substance P, particularly its role in neurotransmission, inflammation, and pain signaling. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, immunology, and drug discovery for neurological and inflammatory disorders.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of neurokinin-1 (NK1) receptor binding, activation, and downstream signaling pathways.
• Pharmacological Assay Development: Serves as a key ligand in competitive binding assays and functional cell-based assays to screen and characterize novel NK1 receptor antagonists.
• Biochemical Studies: Employed to investigate the proteolytic processing and metabolic fate of the full-length Substance P peptide in various biological systems.
• Inflammation & Pain Research: Applied in experimental models to elucidate the role of Substance P fragments in mediating neurogenic inflammation, vasodilation, and nociception (pain perception).
• Peptide Chemistry Reference: Acts as a standard for analytical method development (e.g., HPLC, MS) and for quality control in the synthesis of related peptide analogs.

Basic Information

Product Name	Substance P Fragment 3-11 Acetate
CAS No.	51165-12-9
Molecular Formula	C58H89N17O13S • xC2H4O2
Molecular Weight	1240.5 g/mol (free base)
Synonyms	Substance P (3-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt; SP (3-11); Neurokinin P (3-11); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate; Substance P Fragment 3-11 amide acetate
EINECS	Contact for details

Quality Control

Our Substance P Fragment 3-11 Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC / IC)	2.0 - 8.0 mol/mol peptide
Peptide Content (AAA)	≥ 70%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.