Description

Substance P (3-11) CAS NO 51165-11-8 is a defined bioactive fragment of the full neuropeptide Substance P, specifically encompassing amino acid residues 3 through 11. This peptide is of significant value in neuroscience and pharmacological research for its role as a selective agonist for the neurokinin-1 (NK-1) receptor. It is primarily utilized by research institutions and pharmaceutical developers focused on studying pain pathways, neurogenic inflammation, and central nervous system disorders. The compound offers a critical tool for investigating receptor-ligand interactions and signal transduction mechanisms.

Application

• Neuroscience Research: Used as a selective NK-1 receptor agonist to study pain transmission, neurogenic inflammation, and the role of tachykinins in the central and peripheral nervous systems.
• Pharmacological Screening: Serves as a reference standard and active agent in high-throughput screening assays to identify and characterize novel NK-1 receptor antagonists.
• Cell Signaling Studies: Employed to investigate intracellular signaling pathways, including calcium mobilization and neurotransmitter release, activated by NK-1 receptor stimulation.
• In Vitro & Ex Vivo Models: Applied in tissue bath experiments and primary cell culture systems to model physiological and pathophysiological responses.
• Biochemical Reagent: Functions as a critical reagent in binding assays (e.g., radioimmunoassays) to quantify receptor density and affinity.
• Drug Discovery & Development: Provides a key pharmacophore for the design and efficacy testing of new therapeutic agents targeting the tachykinin system.

Basic Information

Product Name	Substance P (3-11)
CAS No.	51165-11-8
Molecular Formula	C58H86N16O12S
Molecular Weight	1191.5 g/mol
Synonyms	Substance P Fragment 3-11; [pGlu5, MePhe8, Sar9]-Substance P (5-11); (pGlu5, MePhe8, Sar9)-SP(5-11); Senktide; Neurokinin-1 Receptor Agonist; NK-1 Agonist; SP (3-11); Tachykinin Receptor Agonist
EINECS	Contact for details

Quality Control

Our Substance P (3-11) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.