Description

Substance P (6-11) CAS NO 51165-07-2 is a bioactive peptide fragment derived from the neuropeptide Substance P, specifically encompassing amino acid residues 6 through 11. This compound is a critical research tool for investigating the structure-activity relationships and specific biological functions of the C-terminal region of Substance P. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers engaged in neuropharmacology, pain research, and receptor characterization studies.

Application

• Neuroscience Research: Used as a selective agonist/antagonist tool to study the role of Substance P in pain signaling, neuroinflammation, and neurotransmission.
• Receptor Binding Assays: Essential for competitive binding studies to characterize and map neurokinin-1 (NK1) receptor subtypes and affinity.
• Drug Discovery & Development: Serves as a key intermediate or reference standard in the development of novel analgesics and neuropsychiatric therapeutics targeting the tachykinin system.
• Biochemical Pathway Analysis: Employed in cell-based assays and animal models to elucidate downstream signaling cascades activated by Substance P fragments.
• Peptide Synthesis & Conjugation: Acts as a building block or hapten for the synthesis of larger peptide conjugates, antibodies, or diagnostic probes.
• Academic & Institutional Research: A fundamental reagent for university and government labs studying gastrointestinal motility, respiratory function, and immune modulation.

Basic Information

Product Name	Substance P (6-11)
CAS No.	51165-07-2
Molecular Formula	C34H52N10O7S
Molecular Weight	744.91 g/mol
Synonyms	Substance P Fragment 6-11; Arg-Pro-Lys-Pro-Gln-Gln-NH2; H-Arg-Pro-Lys-Pro-Gln-Gln-NH2; SP (6-11); [pGlu6]-Substance P (6-11); Tachykinin Fragment 6-11; Neurokinin P (6-11); Pyr-Arg-Pro-Lys-Pro-Gln-Gln-NH2
EINECS	Contact for details

Quality Control

Our Substance P (6-11) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.