Description

Substance P Fragment 8-11 Acetate Salt is a defined synthetic peptide fragment of the neuropeptide Substance P, specifically corresponding to the amino acid sequence from positions 8 to 11. This compound is a critical research tool for investigating the structure-activity relationships and biological functions of Substance P, particularly its interaction with neurokinin receptors. It is primarily utilized by researchers and scientists in the fields of neuroscience, pharmacology, and biochemical research for use as a reference standard, in receptor binding assays, and for studying peptide metabolism.

Application

• Neuroscience Research: Used as a specific ligand and reference standard in studies of the central and peripheral nervous system.
• Pharmacological Studies: Essential for receptor binding assays and competitive inhibition experiments targeting Neurokinin 1 (NK1) receptors.
• Biochemical Research: Serves as a substrate or intermediate in enzymatic studies and peptide metabolism research.
• Drug Discovery: Acts as a key building block or analog in the development and screening of novel neurokinin receptor antagonists.
• Academic & Institutional Research: A fundamental reagent for university and institutional labs studying neuropeptide signaling pathways.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits for research purposes.

Basic Information

Item	Details
Product Name	Substance P Fragment 8-11 Acetate Salt
CAS No.	51165-03-8
Molecular Formula	C24H40N8O7 • xC2H4O2
Molecular Weight	552.63 g/mol (free base)
Synonyms	Substance P (8-11); SP (8-11); Arg-Pro-Lys-Pro; H-Arg-Pro-Lys-Pro-OH acetate salt; Substance P Fragment 8-11; Neurokinin P (8-11); Tachykinin Fragment 8-11; RPKP acetate
EINECS	Contact for details

Quality Control

Our Substance P Fragment 8-11 Acetate Salt is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and documentation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 10.0%
Acetate Content (IC)	Contact for details
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.