Description

Hemoglobin Southampton CAS NO 51142-53-1 is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting protein in red blood cells. This compound is of significant interest in biochemical research and diagnostic development due to its unique structural and functional properties. It is primarily utilized by researchers and manufacturers in the fields of hematology, clinical diagnostics, and biopharmaceutical development for studying hemoglobinopathies and creating specialized analytical standards.

Application

• Biochemical Research Standard: Serves as a critical reference material for studying the structure, function, and stability of hemoglobin variants.
• Clinical Diagnostics Development: Used in the development and calibration of diagnostic assays and kits for detecting specific hemoglobin disorders.
• Hematology Studies: Essential for in-vitro research into sickle cell disease and other hemoglobinopathies related to the Southampton variant.
• Pharmaceutical R&D: Employed in preclinical research for novel therapeutic approaches targeting abnormal hemoglobin.
• Educational & Reference Material: Supplied to academic and clinical laboratories for teaching and quality control purposes.
• Analytical Method Validation: Acts as a known control substance in techniques like HPLC, electrophoresis, and mass spectrometry for method validation.

Basic Information

Item	Details
Product Name	Hemoglobin Southampton
CAS No.	51142-53-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hemoglobin Southampton variant; Hb Southampton; Hemoglobin variant Southampton; Unstable hemoglobin Southampton; Hb Southhampton (common misspelling); α-2 β-2(145) tyrosine to cysteine (describing the amino acid substitution); Hemoglobin alpha2beta2145(HC3)Tyr->Cys
EINECS	Contact for details

Quality Control

Our Hemoglobin Southampton is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation. For short-term use, keep at 2-8°C. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR / HPLC)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Solubility	Clear solution in buffer
Moisture Content (KF)	≤ 5.0%
Biological Activity (O2 binding)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.