Description

(+-)-Cephalothin CAS NO 51098-29-4 is a semi-synthetic, first-generation cephalosporin antibiotic derived from cephalosporin C. This compound serves as a crucial pharmaceutical reference standard and active pharmaceutical ingredient (API) intermediate for research, development, and quality control processes. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in antibiotic development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of cephalothin in drug substances and finished products via HPLC, LC-MS, and other chromatographic methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key starting material or intermediate in the synthesis of cephalothin sodium, the injectable antibiotic form.
• Microbiological Research: Employed in in vitro studies to determine minimum inhibitory concentrations (MICs) and investigate bacterial resistance mechanisms against β-lactam antibiotics.
• Quality Control & Assurance: Essential for method validation, system suitability testing, and ensuring batch-to-batch consistency in pharmaceutical manufacturing.
• Regulatory Submissions: Provides certified material for stability studies, impurity profiling, and documentation required by agencies like the FDA and EMA.

Basic Information

Product Name	(+-)-Cephalothin
CAS No.	51098-29-4
Molecular Formula	C16H16N2O6S2
Molecular Weight	396.44 g/mol
Synonyms	Cephalothin (racemic mixture); 7-(Thiophene-2-acetamido)cephalosporanic acid; Cefalotin free acid; (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Keflin (related to sodium salt); Cephapirin analog; Cephalosporin 87/312; SQ 13224 (free acid)
EINECS	256-961-2

Quality Control

Our (+-)-Cephalothin is produced and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications are aligned with general requirements for chemical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.