Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[(Acetyloxy)Methyl]-8-Oxo-7-[(2-Thienylacetyl)Amino]-, Monosodium Salt, trans-(+-)- is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is of critical importance in the synthesis of advanced cephalosporin antibiotics, offering a reliable building block for complex pharmaceutical manufacturing. It is primarily needed by pharmaceutical companies, research institutions, and fine chemical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Synthesis: Key intermediate in the production of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API): Serves as the core active component in finished antibiotic formulations.
• Research & Development: Used in medicinal chemistry for the development of new antibacterial compounds and structural analogs.
• Process Chemistry: Employed in scale-up and optimization studies for commercial antibiotic manufacturing.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing.
• Fine Chemical Manufacturing: A critical building block for specialized chemical synthesis in the life sciences sector.

Basic Information

Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[(Acetyloxy)Methyl]-8-Oxo-7-[(2-Thienylacetyl)Amino]-, Monosodium Salt, trans-(+-)-
CAS No.	51014-52-9
Molecular Formula	C16H15N2NaO6S2
Molecular Weight	418.41 g/mol
Synonyms	Cefotaxime Sodium; Sodium Cefotaxime; Cefotaxime Sodium Salt; HR-756 Sodium; Cefotaxim Sodium; Claforan (Brand Name); (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; trans-Cefotaxime Sodium
EINECS	256-963-7

Quality Control

Our Cefotaxime Sodium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with pharmaceutical-grade specifications, including identity, purity, and impurity profile. We provide comprehensive Certificates of Analysis (COA) upon request, detailing results from HPLC, NMR, and other relevant pharmacopeial methods to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
pH (10% solution)	4.5 - 6.5
Specific Optical Rotation	+58° to +64° (c=1 in H2O)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.20 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.