Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(Aminocarbonyl)Oxy]Methyl]-7-Methoxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-, cis-(+-)- is a key advanced pharmaceutical intermediate in the synthesis of modern cephalosporin antibiotics. This compound matters for its role as a crucial building block in creating potent, broad-spectrum antibacterial agents that target resistant pathogens. Pharmaceutical manufacturers and research institutions require this high-purity intermediate for the development and production of next-generation antibiotic formulations.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a critical intermediate in the manufacture of third and fourth-generation cephalosporin antibiotics.
• Antibacterial Drug Development: Serves as a core scaffold in R&D for novel antibiotics targeting multidrug-resistant bacterial infections.
• Pharmaceutical Research: Used in academic and industrial laboratories for structure-activity relationship (SAR) studies and medicinal chemistry optimization.
• Veterinary Medicine Production: Employed in the synthesis of cephalosporin-based treatments for bacterial diseases in animals.
• Process Chemistry & Scale-Up: Integral to developing and optimizing robust, cost-effective synthetic routes for commercial antibiotic production.

Basic Information

Item	Details
Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(Aminocarbonyl)Oxy]Methyl]-7-Methoxy-8-Oxo-7-[(2-Thienylacetyl)Amino]-, cis-(+-)-
CAS No.	51014-44-9
Molecular Formula	C17H17N3O7S2
Molecular Weight	439.46 g/mol
Synonyms	7-ACA Derivative (Thienylacetyl); 7-Methoxy-7-(2-thienylacetamido)-3-[(aminocarbonyl)oxy]methyl-3-cephem-4-carboxylic acid; Cephalosporin C-3 Quaternary Ammonium Salt Intermediate; (6R,7R)-7-Methoxy-7-(2-thienylacetamido)-3-[(aminocarbonyl)oxy]methyl-3-cephem-4-carboxylic acid; cis-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Antibiotic Intermediate 51014-44-9; 7-Methoxy-7-(2-thienylacetamido)cephalosporanic Acid Derivative
EINECS	Contact for details

Quality Control

Our 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid intermediate is produced under strict quality management systems, with specifications designed to meet the rigorous demands of pharmaceutical synthesis. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing purity, identity, and impurity profiles. Our quality protocols are aligned with ICH guidelines and support compliance in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.