Description

5-Methyltetrahydrofolate Triglutamate is the metabolically active, polyglutamated form of folate, a critical cofactor in one-carbon metabolism. This compound is essential for the synthesis of nucleotides and amino acids, making it a vital ingredient for advanced nutritional and pharmaceutical formulations. It is primarily utilized by manufacturers in the nutraceutical, pharmaceutical, and clinical research sectors seeking a highly bioavailable and stable folate source.

Application

• Active Pharmaceutical Ingredient (API) in prescription-grade folate supplements and medications.
• Key component in high-potency prenatal and clinical nutrition formulations.
• Critical raw material for the production of advanced medical foods and dietary supplements.
• Biochemical research reagent for studies in methylation cycles, homocysteine metabolism, and cell proliferation.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Ingredient in specialized fortification programs for functional foods and beverages.

Basic Information

Product Name	5-Methyltetrahydrofolate Triglutamate
CAS No.	50998-20-4
Molecular Formula	C26H35N7O11
Molecular Weight	621.60 g/mol
Synonyms	(6S)-5-Methyl-5,6,7,8-tetrahydrofolic Acid Triglutamate; Metafolin (polyglutamate form); L-Methylfolate Triglutamate; 5-MTHF-Glu3; 5-Methyltetrahydropteroyltriglutamate; (6S)-5-Methyltetrahydroperoyl-L-glutamyl-L-glutamyl-L-glutamic Acid; 5-Methyl-H4PteGlu3
EINECS	Contact for details

Quality Control

Our 5-Methyltetrahydrofolate Triglutamate is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency. Certificates of Analysis (COA) documenting compliance with relevant standards are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its sensitivity, the product should be stored under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/UV)	Conforms
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Microbiological Analysis	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.