Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-8-Oxo-7-[(1H-Tetrazol-1-Ylacetyl)Amino]-, trans-(+-)- is a complex, semi-synthetic β-lactam compound that serves as a key advanced intermediate in the synthesis of modern cephalosporin antibiotics. Its value lies in its structural complexity, which enables the introduction of specific side chains critical for broad-spectrum antibacterial activity and β-lactamase resistance. This high-purity intermediate is essential for pharmaceutical manufacturers and research institutions focused on developing and producing next-generation antibacterial agents to combat resistant pathogens.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced third and fourth-generation cephalosporin antibiotics.
• Antibacterial Drug Development: Used in R&D for creating new β-lactam antibiotics with enhanced efficacy against multi-drug resistant bacteria.
• Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in the multi-step chemical process to manufacture finished antibiotic APIs.
• Pharmacological Research: Employed in structure-activity relationship (SAR) studies to optimize antibiotic potency and pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Utilized in pilot plants and commercial manufacturing for process optimization and validation of cephalosporin production.

Basic Information

Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-8-Oxo-7-[(1H-Tetrazol-1-Ylacetyl)Amino]-, trans-(+-)-
CAS No.	50918-36-0
Molecular Formula	C14H14N8O4S3
Molecular Weight	454.51 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(1H-Tetrazol-1-yl)acetamido]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefmenoxime Intermediate; Cefmenoxime Hydrochloride Intermediate; trans-Cefmenoxime Acid; 7β-[2-(1H-Tetrazol-1-yl)acetamido]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-3-cephem-4-carboxylic acid; SCE-1365 Intermediate; Antibiotic SCE-1365 Precursor
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and traceability. Our quality control protocols are designed to meet the stringent requirements of pharmaceutical GMP guidelines. Every lot is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to confirm its suitability for API synthesis. A detailed Certificate of Analysis (COA) documenting identity, assay, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.