Description

Nα-Boc-Nω-Nitro-D-Arginine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is specifically designed for the controlled introduction of the D-arginine moiety into peptide chains, where the Boc group provides orthogonal protection and the nitro group serves as a precursor to the guanidino functionality. It is a critical building block for pharmaceutical researchers and manufacturers developing novel therapeutic peptides, protease inhibitors, and biochemical tools that require precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Protease Inhibitor Development: Used in research and production of inhibitors targeting trypsin-like serine proteases, where the D-arginine configuration enhances metabolic stability.
• Bioconjugation & Labeling: Serves as a precursor for introducing guanidine-containing tags or linkers into biomolecules for diagnostic and research applications.
• Chemical Biology Probes: Integral for creating activity-based probes and affinity labels to study enzyme function and protein-protein interactions.
• API Synthesis: Employed in the synthetic pathways of active pharmaceutical ingredients (APIs) that incorporate non-natural amino acid architectures.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on peptide chemistry, medicinal chemistry, and drug discovery programs.

Basic Information

Product Name	Nα-Boc-Nω-Nitro-D-Arginine
CAS No.	50913-12-7
Molecular Formula	C11H21N5O6
Molecular Weight	319.32 g/mol
Synonyms	Boc-D-Arg(NO2)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-5-(nitroguanidino)pentanoic acid; D-2-Amino-5-[(nitroamino)iminomethyl]amino]pentanoic acid N-tert-butoxycarbonyl; tert-Butoxycarbonyl-D-arginine(NG-nitro); Boc-D-Arg(NO2); Nα-Boc-Nω-nitro-D-arginine; D-Boc-Arg(NO2); N-tert-Butoxycarbonyl-NG-nitro-D-arginine
EINECS	Contact for details

Quality Control

Our Nα-Boc-Nω-Nitro-D-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm D-configuration, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.