Description

Z-Ala-Ile-Oh is a protected dipeptide building block, specifically the Z-protected derivative of the alanine-isoleucine dipeptide with a free carboxylic acid terminus. This compound is a critical intermediate in the synthesis of more complex peptides and peptidomimetics, offering precise control over sequence and stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, medicinal chemistry, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected fragment for the sequential assembly of custom peptide sequences in both research and development settings.
• Solution-Phase Peptide Synthesis: Used as a coupling unit in the synthesis of specific peptide segments or smaller oligopeptides.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of potential therapeutic peptides targeting various diseases.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, peptide hormone analogs, and structure-activity relationship (SAR) studies.
• Peptidomimetic Development: Acts as a starting material for creating modified peptide structures with enhanced stability or biological activity.
• Academic Research & Teaching: Used in university laboratories for training in advanced organic synthesis and peptide chemistry techniques.

Basic Information

Product Name	Z-Ala-Ile-Oh
CAS No.	50903-75-8
Molecular Formula	C20H28N2O6
Molecular Weight	392.45 g/mol
Synonyms	N-Benzyloxycarbonyl-L-alanyl-L-isoleucine; Z-L-Ala-L-Ile-OH; CBZ-L-Ala-L-Ile-OH; N-CBZ-L-Alanyl-L-Isoleucine; Benzyloxycarbonylalanylisoleucine; (2S)-2-[[(2S)-2-[[(phenylmethoxy)carbonyl]amino]propanoyl]amino]-3-methylpentanoic acid; Z-A-I-OH; Nα-Cbz-L-Ala-L-Ile-OH
EINECS	Contact for details

Quality Control

Our Z-Ala-Ile-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.