Description

6-o-Methyl-D3-Guanine is a deuterium-labeled isotopologue of the nucleobase derivative O6-methylguanine. This compound is a critical stable isotope-labeled internal standard used for precise quantification in advanced analytical techniques. It is essential for researchers and quality control laboratories in the pharmaceutical and life sciences sectors who require high-purity reference materials for method development and validation.

Application

• Mass Spectrometry Internal Standard: Used as a deuterated standard for the accurate quantification of O6-methylguanine and related adducts in LC-MS/MS and GC-MS analyses.
• Biomarker Research: Critical in studies of DNA alkylation damage, oxidative stress, and carcinogenesis for precise measurement of biomarker levels.
• Pharmacokinetic & Metabolomic Studies: Enables reliable tracking and quantification of drug metabolites and endogenous compounds in complex biological matrices.
• Diagnostic Assay Development: Serves as a calibrant or reference compound in the development of clinical diagnostic tests for genetic or metabolic disorders.
• Toxicology and Environmental Monitoring: Applied in assays to measure exposure to alkylating agents and environmental toxins.
• Quality Control (QC) in Pharma: Used in-house by manufacturers to validate analytical methods for impurity profiling and stability testing of pharmaceuticals.

Basic Information

Product Name	6-o-Methyl-D3-Guanine
CAS No.	50704-43-3
Molecular Formula	C6H4D3N5O
Molecular Weight	153.15 g/mol
Synonyms	O6-Methyl-D3-guanine; 2-Amino-6-(methyl-d3)-1,7-dihydro-6H-purin-6-one; Guanin-6-o-methyl-d3; 6-(Methoxy-d3)guanine; Deuterated O6-Methylguanine; [D3]-O6-Methylguanine; 6-Methoxy-d3-purine-2-amine
EINECS	Contact for details

Quality Control

Our 6-o-Methyl-D3-Guanine is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.