Description

N-(Hydroxymethyl)Trifluoroacetamide is a versatile trifluoromethylated building block and a key intermediate in organic synthesis. Its value lies in the unique reactivity of the hydroxymethyl group and the stability imparted by the trifluoroacetamide moiety, enabling the introduction of fluorine-containing groups into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and prodrugs, leveraging the trifluoromethyl group to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental persistence.
• Peptide Modification: Serves as a protecting group or a functional handle for the selective modification of amino acids and peptides in biochemical research.
• Material Science Precursor: Employed in the development of specialty polymers, coatings, and liquid crystals that require fluorinated components for specific thermal, chemical, or surface properties.
• Cross-linking Agent: Utilized in resin and polymer chemistry where the hydroxymethyl group can participate in condensation reactions to form stable networks.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing diverse heterocyclic and acyclic compounds in academic and industrial R&D labs.

Basic Information

Product Name	N-(Hydroxymethyl)Trifluoroacetamide
CAS No.	50667-69-1
Molecular Formula	C3H4F3NO2
Molecular Weight	143.06 g/mol
Synonyms	2,2,2-Trifluoro-N-(hydroxymethyl)acetamide; Trifluoroacetamide, N-(hydroxymethyl)-; Hydroxymethyltrifluoroacetamide; N-Hydroxymethyl-2,2,2-trifluoroacetamide; (Trifluoroacetylamino)methanol; N-Methanoltrifluoroacetamide; α-(Trifluoroacetamido)methanol
EINECS	Contact for details

Quality Control

Our N-(Hydroxymethyl)Trifluoroacetamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.