Description

1-Bromo-1-Butyne is a highly reactive halogenated alkyne building block, essential for advanced organic synthesis. Its terminal bromine and alkyne functionality make it a versatile precursor for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This compound is critical for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for introducing alkyne moieties for click chemistry or further functionalization.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its reactive groups enable the creation of potent bioactive molecules.
• Material Science Research: Employed in the development of polymers, dendrimers, and other advanced materials requiring precise alkyne incorporation.
• Organic Synthesis Building Block: A fundamental reagent for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a precursor for labeling reagents and molecular probes used in bio-conjugation and imaging studies.

Basic Information

Item	Details
Product Name	1-Bromo-1-Butyne
CAS No.	50405-39-5
Molecular Formula	C₄H₅Br
Molecular Weight	132.99 g/mol
Synonyms	1-Butyne, 1-bromo-; But-1-yn-1-yl bromide; 1-Butynyl bromide; Bromobut-1-yne; 1-Bromobut-1-yne; Terminal bromobutylene
EINECS	Contact for details

Quality Control

Our 1-Bromo-1-Butyne is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and FTIR, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.