Description

Boc-His(Z)-Oh CAS NO 50305-43-6 is a protected derivative of the amino acid L-Histidine, featuring both tert-butoxycarbonyl (Boc) and benzyloxycarbonyl (Z) protecting groups. This dual protection is critical for enabling selective deprotection strategies during complex peptide synthesis, ensuring high fidelity and yield. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of histidine residues into peptide chains, especially in Fmoc/Boc strategies.
• Pharmaceutical Research: Used in the R&D of novel peptide-based drugs, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Serves as a modified amino acid for creating custom peptide-protein conjugates or labeled peptides for diagnostic assays.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Biochemical Research: Fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and peptide self-assembly.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech industry.

Basic Information

Product Name	Boc-His(Z)-Oh
CAS No.	50305-43-6
Molecular Formula	C₁₈H₂₃N₃O₆
Molecular Weight	377.40 g/mol
Synonyms	Nα-Boc-Nim-Z-L-histidine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-((benzyloxy)carbonyl)-1H-imidazol-4-yl)propanoic acid; Boc-His(Bzl)-OH; Boc-L-histidine(Nim-Z)-OH; Nα-Boc-Nim-Cbz-L-histidine; tert-Butyloxycarbonyl-L-histidine(benzyloxycarbonyl); Boc-His(Z)-OH DCHA salt (when applicable); BOC-HIS(Z)-OH
EINECS	Contact for details

Quality Control

Our Boc-His(Z)-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Specific Rotation	-5.0° to -7.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.