Description

Retrobradykinin is a synthetic peptide analog of the endogenous vasoactive peptide bradykinin, identified by CAS No. 5991-13-9. This compound is a critical research tool for investigating the kinin-kallikrein system, which plays a fundamental role in inflammation, blood pressure regulation, and pain signaling. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cardiovascular, inflammatory, and neuropharmacological studies.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies targeting bradykinin B1 and B2 receptors to understand their physiological and pathophysiological roles.
• Drug Discovery & Development: Serves as a key molecular tool for screening and validating new therapeutic candidates for conditions like hypertension, chronic pain, and angioedema.
• Biochemical Assays: Employed in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other in vitro test systems to quantify bradykinin pathway activity.
• Academic & Clinical Studies: Facilitates basic science research into inflammatory cascades, vascular permeability, and nociception (pain perception).
• Peptide Chemistry Reference: Acts as a model compound for studying peptide stability, metabolism, and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Retrobradykinin
CAS No.	5991-13-9
Molecular Formula	C₅₀H₇₃N₁₅O₁₁
Molecular Weight	1060.2 g/mol
Synonyms	Retrobradykinin; Bradykinin, retro-; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH (retro sequence); Retro-BK; [Retro]-bradykinin; Kallidin I, retro-; 5991-13-9
EINECS	Contact for details

Quality Control

Our Retrobradykinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and stringent controls for residual solvents and endotoxins. A detailed Certificate of Analysis (COA) is provided, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.