Description

(6R-Trans)-3-(Hydroxymethyl)-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid CAS NO 5935-65-9 is a key pharmaceutical intermediate, specifically a derivative of the cephalosporin class of β-lactam antibiotics. Its primary value lies in its role as a critical building block for the synthesis of advanced antibiotic compounds, ensuring high-purity inputs for complex pharmaceutical manufacturing. This product is essential for R&D laboratories and production facilities in the pharmaceutical and fine chemical industries focused on developing and producing next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for novel antibacterial drug candidates.
• Biochemical Research: Serves as a standard or reagent in studies investigating β-lactam structure-activity relationships and resistance mechanisms.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, high-value molecules with specific stereochemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antibiotic formulations.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.

Basic Information

Item	Details
Product Name	(6R-Trans)-3-(Hydroxymethyl)-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	5935-65-9
Molecular Formula	C15H14N2O6S2
Molecular Weight	382.41 g/mol
Synonyms	7-(2-Thienylacetamido)cephalosporanic Acid; 7-(2-Thienylacetamido)-3-hydroxymethyl-3-cephem-4-carboxylic Acid; 7-TACA; 7-(2-Thienylacetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin 7-TACA Derivative; (6R,7R)-7-[(2-Thiopheneacetyl)amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (6R-Trans)-3-(Hydroxymethyl)-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (6R,7R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.