Description

4-(Difluoromethoxy)Bromobenzene is a versatile aromatic building block characterized by its bromine and difluoromethoxy substituents. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the difluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form biaryl structures.
• Functional Material Research: Employed in academic and industrial labs for creating novel polymers, ligands, and advanced organic frameworks with specific electronic properties.
• Fluorine Chemistry Studies: A valuable reagent for investigating the effects of fluorine substitution in medicinal and material chemistry.

Basic Information

Product Name	4-(Difluoromethoxy)Bromobenzene
CAS No.	5905-69-1
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)bromobenzene; 4-Bromo-1-(difluoromethoxy)benzene; Benzene, 1-bromo-4-(difluoromethoxy)-; Bromobenzene, 4-(difluoromethoxy)-; (4-Bromophenyl)difluoromethyl ether; p-Bromo(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.