Description

n-Benzoyl-L-Proline is a high-purity, protected amino acid derivative of significant commercial and research interest. This compound serves as a crucial chiral building block and intermediate in the synthesis of complex pharmaceutical molecules and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting cardiovascular and neurological conditions.
• Peptide Synthesis: Used as a protected proline derivative in solid-phase and solution-phase peptide synthesis to construct peptide chains with specific conformational properties.
• Protease Inhibitor Research: Serves as a scaffold or precursor in the development of enzyme inhibitors, including those for angiotensin-converting enzyme (ACE).
• Asymmetric Catalysis: Employed as a ligand or precursor for chiral catalysts used in asymmetric synthesis.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme mechanisms and protein-protein interactions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	n-Benzoyl-L-Proline
CAS No.	5874-58-8
Molecular Formula	C₁₃H₁₅NO₃
Molecular Weight	233.26 g/mol
Synonyms	L-Proline, N-benzoyl-; (S)-1-(Benzoyl)pyrrolidine-2-carboxylic acid; N-Benzoyl-L-proline; Bz-Pro-OH; N-α-Benzoyl-L-proline; Benzoylproline; NSC 3349; 2-Pyrrolidinecarboxylic acid, 1-benzoyl-, (S)-
EINECS	227-525-9

Quality Control

Our n-Benzoyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer or pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.