Description

2'-Chloro-2,2,2-trifluoroacetophenone is a versatile and high-purity fluorinated aromatic ketone building block. This compound is valued for its unique trifluoromethyl and chloro substituents, which impart significant electronic and steric properties critical for advanced synthesis. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries. The material serves as a key intermediate in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and specialty crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique optical and electronic properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the 2-chloro-α,α,α-trifluoroacetophenone moiety into complex molecular architectures.
• Fluorine Chemistry Studies: An important standard and reactant in academic and industrial research focused on organofluorine chemistry and reaction mechanism studies.

Basic Information

Product Name	2'-Chloro-2,2,2-trifluoroacetophenone
CAS No.	5860-95-7
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoroacetophenone; 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone; o-Chloro-α,α,α-trifluoroacetophenone; 2-Chlorophenyl trifluoromethyl ketone; 2'-Chloro-α,α,α-trifluoroacetophenone; 2-Chlorobenzoyl trifluoromethane; (2-Chlorophenyl)(trifluoromethyl)methanone
EINECS	227-500-6

Quality Control

Our 2'-Chloro-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.