Description

Methenamine Hippurate is a white to off-white crystalline powder, recognized for its role as a urinary tract antiseptic. This compound is valued for its ability to hydrolyze in acidic urine to release formaldehyde, providing a broad-spectrum antibacterial effect. It is primarily required by pharmaceutical manufacturers for the formulation of prescription and over-the-counter medications targeting uncomplicated urinary tract infections.

Application

• Pharmaceutical API: Primary active pharmaceutical ingredient (API) in prescription and OTC medications for the prophylaxis and treatment of uncomplicated lower urinary tract infections (UTIs).
• Veterinary Medicine: Used in veterinary pharmaceutical formulations for the treatment of bacterial infections in animals, particularly in companion animals and livestock.
• Clinical Research: Serves as a reference standard and key intermediate in pharmacological and microbiological research studies.
• Finished Dosage Forms: Incorporated into various solid oral dosage forms, including tablets and capsules, requiring precise and consistent API quality.

Basic Information

Product Name	Methenamine Hippurate
CAS No.	5714-73-8
Molecular Formula	C9H15N4O3
Molecular Weight	227.24 g/mol
Synonyms	Hexamine Hippurate; Methenamine 2-Hydroxy-3,3-dimethylbutanedioate; Hippuric Acid Methenamine Salt; 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane Hippurate; Hexamethylenetetramine Hippurate; Urotropin Hippurate; Methenamine Mono(hippurate); HIPREX (a common trade name)
EINECS	227-206-5

Quality Control

Our Methenamine Hippurate is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing to ensure identity, purity, strength, and composition. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Microbial Enumeration	Meets USP/EP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.