Description

Posaconazole is a broad-spectrum triazole antifungal agent used in the prevention and treatment of serious fungal infections. Its efficacy against a wide range of pathogens, including Aspergillus and Candida species, makes it a critical component in clinical and pharmaceutical settings. This compound is essential for manufacturers of antifungal medications, pharmaceutical intermediates, and research institutions focused on developing new therapeutic formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of oral suspensions, delayed-release tablets, and intravenous solutions for systemic antifungal therapy.
• Prophylaxis and Treatment: Used in medications to prevent and treat invasive aspergillosis and candidiasis in immunocompromised patients, such as those undergoing chemotherapy or organ transplantation.
• Research & Development: Serves as a key reference standard and building block in microbiological research and the development of new antifungal agents.
• Veterinary Pharmaceuticals: Potential application in antifungal treatments for animals.
• Intermediate Synthesis: Used in the chemical synthesis of more complex antifungal compounds and derivatives.

Basic Information

Product Name	Posaconazole
CAS No.	171228-49-2
Molecular Formula	C37H42F2N8O4
Molecular Weight	700.78 g/mol
Synonyms	SCH 56592; Noxafil; Posaconazol; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-{4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1,2,4-oxadiazol-3-yl)butan-2-ol
EINECS	Contact for details

Quality Control

Our Posaconazole is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is tested against rigorous specifications, including identity, purity, and impurity profiles, with methods aligned with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.