Description

Gardiquimod is a potent and selective small molecule agonist for Toll-like receptor 7 (TLR7), a key component of the innate immune system. This compound is of significant value in pharmaceutical research and development for its ability to stimulate a robust immune response. It is primarily utilized by researchers and manufacturers in the fields of immunology, antiviral drug discovery, and vaccine adjuvant development, where modulating immune pathways is critical.

Application

• Immunological Research: As a tool compound for studying TLR7 signaling pathways and innate immune activation in vitro and in vivo.
• Antiviral Drug Development: Investigation as a potential therapeutic agent or lead compound for treating viral infections by enhancing the body's antiviral defenses.
• Vaccine Adjuvant Research: Evaluation for its potential to enhance the efficacy of vaccines by promoting a stronger and more targeted immune response.
• Oncology Research: Exploration in cancer immunotherapy studies to stimulate immune cells against tumors.
• Dermatology Research: Study of its effects in models of skin conditions where immune modulation is beneficial.
• Biochemical Assay Development: Used as a standard or control in high-throughput screening assays targeting TLR7 activity.

Basic Information

Product Name	Gardiquimod
CAS No.	1020412-43-4
Molecular Formula	C₁₇H₂₂N₈O₂
Molecular Weight	370.41 g/mol
Synonyms	1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol; Gardiquimod; TLR7 agonist; 1-[4-Amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanol; Imiquimod analog; R-848 analog; S-27609; Chemical name per IUPAC: 1-[4-Amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
EINECS	Contact for details

Quality Control

Our Gardiquimod is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.