Description

Tolnaftate CAS NO 2398-96-1 is a synthetic thiocarbamate derivative widely recognized as a highly effective topical antifungal agent. Its primary value lies in its potent fungistatic and fungicidal activity against a broad spectrum of dermatophytes and yeasts, which are common causes of skin infections. This makes it an essential active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical and personal care industries, specifically for formulating over-the-counter and prescription antifungal creams, powders, sprays, and solutions.

Application

• Topical Antifungal Formulations: Primary API in creams, ointments, lotions, powders, and sprays for treating athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis).
• Personal Care Products: Key ingredient in medicated foot care products, antifungal soaps, and deodorants designed for fungal infection prevention.
• Veterinary Pharmaceuticals: Used in topical preparations for treating fungal skin infections in companion animals and livestock.
• Combination Therapies: Formulated alongside other antifungal or anti-inflammatory agents in compounded medications for enhanced therapeutic effect.
• Industrial Preservation: Potential use as a fungistatic agent in specific material preservation applications where mold and mildew control is required.

Basic Information

Product Name	Tolnaftate
CAS No.	2398-96-1
Molecular Formula	C19H17NOS
Molecular Weight	307.41 g/mol
Synonyms	O-2-Naphthyl m,N-dimethylthiocarbanilate; Tolnaftatum; Tolmicen; Tinactin (Trade Name); Tonoftal; Focusan; 1,2-Dihydro-N-methyl-2-naphthyl carbamothioate; N-Methyl-N-(3-tolyl)thiocarbamic acid O-2-naphthyl ester
EINECS	219-253-7

Quality Control

Our Tolnaftate is manufactured and tested under a strict quality management system to ensure it meets the highest standards for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling, to confirm compliance with relevant pharmacopeial monographs (such as USP/EP) and customer-specific requirements. A detailed Certificate of Analysis (COA) documenting purity, physical characteristics, and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets USP/EP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.