Description

S(+)-Methadone Hydrochloride Inactive Enantiomer O is the optically pure, pharmaceutically inactive enantiomer of methadone hydrochloride. This high-purity chiral building block is critical for research and development in analytical chemistry and pharmacology, particularly for use as a reference standard. It is essential for scientists and quality control laboratories requiring precise materials for method validation, impurity profiling, and enantiomeric excess determination. This compound is primarily utilized in pharmaceutical R&D, forensic analysis, and academic research.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral impurity standard for the assay and impurity profiling of active pharmaceutical ingredients (APIs) like levomethadone.
• Analytical Method Development: Used in HPLC, GC, and chiral separation method development and validation to ensure accurate detection and quantification.
• Pharmacological Research: Employed in preclinical studies to understand the stereoselective metabolism, pharmacokinetics, and receptor binding of methadone enantiomers.
• Forensic Toxicology: Acts as a certified reference material (CRM) for the precise identification and quantification of methadone and its isomers in forensic samples.
• Quality Control (QC) Testing: Essential for in-house QC laboratories to verify the enantiomeric purity of bulk active pharmaceutical ingredients and finished drug products.
• Academic & Educational Use: Provides a well-defined compound for teaching and research in medicinal chemistry, stereochemistry, and analytical techniques.

Basic Information

Product Name	S(+)-Methadone Hydrochloride Inactive Enantiomer O
CAS No.	5653-80-5
Molecular Formula	C21H28ClNO
Molecular Weight	345.91 g/mol
Synonyms	(S)-(+)-Methadone Hydrochloride; (S)-Methadone HCl; Dextromethadone Hydrochloride (inactive enantiomer); (2S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride; (+)-Methadone Hydrochloride; S-Methadone HCl; Inactive Methadone Enantiomer; CAS 5653-80-5
EINECS	Contact for details

Quality Control

Our S(+)-Methadone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and specific tests. We support compliance with relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.