Description

Pyrrolidine-2-Carbonitrile CAS NO 5626-49-3 is a versatile heterocyclic nitrile building block, serving as a key chiral intermediate in sophisticated organic synthesis. Its pyrrolidine core and reactive nitrile group make it invaluable for constructing complex molecular architectures with high stereochemical control. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery and the production of advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require specific stereochemistry for efficacy.
• Ligand and Catalyst Precursor: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Employed in medicinal chemistry to design and synthesize peptidomimetic compounds, where the pyrrolidine ring mimics natural amino acid structures.
• Material Science: Investigated as a monomer or functional additive in the development of specialized polymers and advanced materials.

Basic Information

Product Name	Pyrrolidine-2-Carbonitrile
CAS No.	5626-49-3
Molecular Formula	C5H8N2
Molecular Weight	96.13 g/mol
Synonyms	2-Cyanopyrrolidine; (S)-(-)-2-Pyrrolidinecarbonitrile; Prolinenitrile; L-Prolinenitrile; 2-Pyrrolidinecarbonitrile; Pyrrolidine-2-carbonitrile; Pyrrolidin-2-yl cyanide; 1-Azabicyclo[3.3.0]octane-2-carbonitrile (related bicyclic form)
EINECS	227-062-7

Quality Control

Our Pyrrolidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong acids. For long-term storage, consider maintaining under an inert atmosphere to preserve optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.