Description

cis-Thiothixene is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant importance in medicinal chemistry. Its primary value lies in its role as a key isomer in the synthesis and research of thioxanthene-based neuroleptic agents. This compound is essential for pharmaceutical R&D laboratories, chemical manufacturers, and academic institutions focused on developing and studying antipsychotic therapeutics. Precise control over the cis-isomer is critical for ensuring the efficacy and safety profile of final drug products.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of the antipsychotic drug Thiothixene (Navane).
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research studies for central nervous system (CNS) disorders.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Medicinal Chemistry Studies: Utilized in structure-activity relationship (SAR) studies to optimize neuroleptic drug profiles.
• Process Development: Employed in the development and scaling of robust, GMP-compliant manufacturing processes for thioxanthene derivatives.
• Metabolite Synthesis: Used as a precursor for synthesizing potential drug metabolites for toxicological and pharmacokinetic studies.

Basic Information

Product Name	cis-Thiothixene
CAS No.	5591-45-7
Molecular Formula	C₂₃H₂₉N₃O₂S₂
Molecular Weight	443.62 g/mol
Synonyms	(Z)-Thiothixene; cis-Tiotixene; (Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide; (Z)-Tiotixene; (9Z)-N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide; cis-Isomer of Thiothixene; Z-Thiothixene; Navane (cis-isomer)
EINECS	Contact for details

Quality Control

Our cis-Thiothixene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. We provide full traceability and detailed Certificates of Analysis (COA) that include results from HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles where applicable, supporting your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Area Percent)
Related Substances (HPLC)	Total impurities ≤ 2.0%
trans-Thiothixene (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.