Description

Benzyl n-Benzyloxycarbonylglycinate is a protected amino acid derivative, specifically the benzyl ester of N-Cbz-glycine. This compound is a crucial building block in peptide synthesis, where it serves to protect the amino terminus of glycine, allowing for selective reactions during the construction of complex peptide chains. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the production of peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of peptides, protecting the glycine residue.
• Pharmaceutical Research: Used in the development and scale-up of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation Chemistry: Serves as a reagent for introducing glycine linkers or spacers in the modification of proteins and other biomolecules.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Fine Chemical Production: Acts as a specialized synthon for the manufacture of custom peptides, flavors, and fragrances.
• Academic Research: Utilized in university and institutional labs for studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	Benzyl n-Benzyloxycarbonylglycinate
CAS No.	5513-38-2
Molecular Formula	C17H17NO4
Molecular Weight	299.32 g/mol
Synonyms	N-Carbobenzoxyglycine Benzyl Ester; Cbz-Gly-OBzl; Benzyl N-Carbobenzyloxyglycinate; Benzyl (Benzyloxycarbonyl)glycinate; Z-Gly-OBzl; N-(Benzyloxycarbonyl)glycine Benzyl Ester; Glycine, N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester; BOC-Gly-OBzl (common misnomer, correct abbreviation is Cbz)
EINECS	226-854-5

Quality Control

Our Benzyl n-Benzyloxycarbonylglycinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	82 - 86 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.