Description

3-Chloro-2-Hydroxy-3-Methyl-2-Phenyl-Butanenitrile is a versatile chiral building block and synthetic intermediate of significant importance in fine chemical synthesis. Its unique structure, featuring both chloro and hydroxy functional groups on a tertiary carbon, makes it a valuable precursor for the preparation of complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Fine Chemical Synthesis: Employed in the multistep synthesis of complex natural products, flavors, and fragrances.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing specialized polymers with unique properties.

Basic Information

Product Name	3-Chloro-2-Hydroxy-3-Methyl-2-Phenyl-Butanenitrile
CAS No.	5445-33-0
Molecular Formula	C11H12ClNO
Molecular Weight	209.67 g/mol
Synonyms	2-Chloro-2-hydroxy-3-methyl-3-phenylbutyronitrile; 3-Chloro-3-methyl-2-oxo-2-phenylbutyronitrile; α-Chloro-α-hydroxy-α-methyl-α-phenylbutyronitrile; 2-Phenyl-2-hydroxy-3-methyl-3-chlorobutyronitrile; 3-Methyl-3-chloro-2-hydroxy-2-phenylbutyronitrile; α-Hydroxy-α-phenyl-α-chloroisobutyronitrile; Butanenitrile, 3-chloro-2-hydroxy-3-methyl-2-phenyl-
EINECS	226-642-3

Quality Control

Our 3-Chloro-2-Hydroxy-3-Methyl-2-Phenyl-Butanenitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.