Description

2-Acetamidoacrylic Acid is a versatile, high-purity organic building block characterized by its reactive acrylic acid and acetamide functionalities. This compound is essential for the synthesis of complex molecules, offering a critical handle for constructing peptide mimetics and other pharmacologically active structures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the preparation of novel drug candidates, particularly for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Synthesis: Serves as a dehydroalanine equivalent for constructing conformationally constrained peptides and mimetics in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides and plant growth regulators with novel modes of action.
• Polymer Modification: Acts as a functional monomer for introducing reactive amide groups into specialty polymers and coatings.
• Bioconjugation Chemistry: Utilized as a linker or spacer molecule in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and other tools for studying enzymatic function.

Basic Information

Product Name	2-Acetamidoacrylic Acid
CAS No.	5429-56-1
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	N-Acetyldehydroalanine; Acetamidoacrylic Acid; 2-Acetamidoprop-2-enoic Acid; (Z)-2-Acetamidoacrylic Acid; Dehydro-N-acetylalanine; NSC 163082; 2-Propenoic acid, 2-(acetylamino)-
EINECS	226-590-1

Quality Control

Our 2-Acetamidoacrylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.