Description

Chloroquine Related Compound E is a high-purity chemical reference standard and synthetic intermediate of significant importance in pharmaceutical research and development. This compound is critical for analytical method development, quality control, and impurity profiling in the production of antimalarial and related therapeutic agents. It serves as an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, well-characterized materials for their processes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity testing of Chloroquine and its derivatives in compliance with pharmacopeial methods (e.g., USP, EP).
• Process Impurity Profiling: A key marker for monitoring and controlling related substances during the synthesis and purification of Chloroquine Active Pharmaceutical Ingredients (APIs).
• Metabolite & Degradation Studies: Employed in research to study the metabolic pathways, stability, and degradation products of Chloroquine-based drugs.
• Analytical Method Development: Serves as a critical component for developing and validating chromatographic methods (HPLC, LC-MS) in quality control laboratories.
• Organic Synthesis Intermediate: Acts as a precursor or a building block in the custom synthesis of novel quinoline-based compounds for biological screening.
• Regulatory Compliance & Documentation: Essential for preparing regulatory submission dossiers (e.g., for FDA, EMA) that require full characterization of impurities and degradation products.

Basic Information

Product Name	Chloroquine Related Compound E
CAS No.	5428-61-5
Molecular Formula	C₁₈H₂₆ClN₃
Molecular Weight	319.87 g/mol
Synonyms	4-(4-Diethylamino-1-methylbutylamino)-7-chloroquinoline; 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; N4-(7-Chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine; Chloroquine Impurity E; Chloroquine EP Impurity E; Chloroquine Related Substance E
EINECS	Contact for details

Quality Control

Our Chloroquine Related Compound E is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical reference standards. A comprehensive Certificate of Analysis (COA) detailing all test results and traceability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.