Description

1,3,7-Trimethyluric Acid is a high-purity, synthetic xanthine derivative of significant commercial and research interest. This compound serves as a critical intermediate and reference standard in the development and quality control of pharmaceutical and nutraceutical products. It is primarily sought by manufacturers and R&D laboratories in the pharmaceutical, analytical chemistry, and life science sectors for its role in metabolic studies and as a precursor for specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced xanthine-based drug candidates and active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Certified material for use in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical methods for quality control and metabolic profiling.
• Biochemical Research: Used in studies of purine metabolism, enzymatic pathways (e.g., involving cytochrome P450), and as a model compound in pharmacokinetic and toxicological research.
• Nutraceutical Ingredient Analysis: Employed as a standard for the assay and impurity profiling in caffeine-related dietary supplements and natural product extracts.
• Fine Chemical Synthesis: Valuable precursor for the preparation of more complex, selectively methylated xanthine derivatives with tailored biological activity.

Basic Information

Item	Detail
Product Name	1,3,7-Trimethyluric Acid
CAS No.	5415-44-1
Molecular Formula	C8H10N4O3
Molecular Weight	210.19 g/mol
Synonyms	1,3,7-Trimethyluric Acid; 1,3,7-Trimethyl-2,6,8-trihydroxypurine; 1,3,7-Trimethyl-2,6,8-trioxopurine; 1,3,7-Trimethyl-2,6,8-purinetrione; TMUA; Theacrine (Note: Theacrine is a closely related natural analog, often used interchangeably in commerce); 8-Oxocaffeine; 1,3,7-Trimethyl-2,6,8(1H,3H,7H)-purinetrione
EINECS	226-527-8

Quality Control

Our 1,3,7-Trimethyluric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and other relevant pharmacopeial tests. Our quality commitment aligns with cGMP principles where applicable, ensuring the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.