Description

Prochlorperazine-D8 2Hcl (Piperazine-D8) is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is specifically designed for use in advanced mass spectrometry, enabling accurate pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on developing and validating bioanalytical methods for prochlorperazine and related phenothiazine derivatives.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled reference compound for the quantitative analysis of prochlorperazine in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in method development for the precise detection and quantification of prochlorperazine in forensic analysis and therapeutic drug monitoring.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of potential genotoxic impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Biomedical Research: Supports academic and industrial research investigating the mechanisms of action, stability, and bioavailability of phenothiazine-class drugs.

Basic Information

Product Name	Prochlorperazine-D8 2Hcl (Piperazine-D8)
CAS No.	5374-32-3
Molecular Formula	C₂₀H₂₆D₈ClN₃S • 2HCl
Molecular Weight	~ 492.0 g/mol (deuterated form)
Synonyms	Prochlorperazine-d8 Dihydrochloride; 2-Chloro-10-[3-(4-methyl-1-piperazinyl-d8)propyl]phenothiazine Dihydrochloride; Compazine-d8; Prochlorperazine (piperazine-d8) Dihydrochloride; 1-[(3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-4-methylpiperazine-d8 Dihydrochloride; Stemetil-d8; CAS 5374-32-3
EINECS	Contact for details

Quality Control

Every batch of Prochlorperazine-D8 2Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Our quality commitment includes verification of deuterium incorporation, chemical purity, and absence of unlabeled analog. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and related substances by HPLC and NMR. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.