Description

2,3,4,5-Tetrafluoro-Benzoic Acid Methyl Ester is a highly fluorinated aromatic ester, a key building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution pattern, which is critical for modifying molecular interactions and stability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors, where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorinated aromatic core contributes to improved efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, influencing dielectric anisotropy and charge transport properties.
• Polymer Modification: Incorporated as a monomer or modifier to create fluorinated polymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce complex, fluorinated benzoate motifs.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	2,3,4,5-Tetrafluoro-Benzoic Acid Methyl Ester
CAS No.	5292-42-2
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	Methyl 2,3,4,5-Tetrafluorobenzoate; Benzoic Acid, 2,3,4,5-Tetrafluoro-, Methyl Ester; 2,3,4,5-Tetrafluorobenzoic Acid Methyl Ester; Methyl Tetrafluorobenzoate; Tetrafluoromethyl Benzoate; 5292-42-2; MFCD00042330
EINECS	226-124-4

Quality Control

Every batch of our 2,3,4,5-Tetrafluoro-Benzoic Acid Methyl Ester is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee consistent quality and traceability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.