Description

n-[p-Toluenesulfonyl]-L-Lysine Methyl Ester Hydrochloride CAS NO 5266-48-8 is a protected amino acid derivative, specifically a tosylated lysine methyl ester salt, widely used as a key synthetic intermediate in peptide chemistry and pharmaceutical research. Its primary value lies in providing a reactive, protected form of L-lysine, enabling selective peptide bond formation and modification while safeguarding the side-chain amine group. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for the synthesis of complex peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A crucial protected amino acid building block for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: Used in the preparation of modified peptides for bioconjugation, fluorescent labeling, or probe development.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new peptide structures and biological activities.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening.
• Enzyme Substrate Synthesis: Used to prepare specific peptide substrates for studying enzyme kinetics and inhibition.

Basic Information

Product Name	n-[p-Toluenesulfonyl]-L-Lysine Methyl Ester Hydrochloride
CAS No.	5266-48-8
Molecular Formula	C15H24N2O4S • HCl
Molecular Weight	364.89 g/mol
Synonyms	N(alpha)-Tosyl-L-lysine methyl ester hydrochloride; N(6)-Tosyl-L-lysine methyl ester hydrochloride; L-Lysine, N2-[(4-methylphenyl)sulfonyl]-, methyl ester, hydrochloride; Methyl N(alpha)-tosyl-L-lysinate hydrochloride; Tos-Lys-OMe • HCl; N(alpha)-Tosyl-L-lysine methylester hydrochloride; N(alpha)-Tosyl-L-lysine methyl ester HCl; p-Toluenesulfonyl-L-lysine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our n-[p-Toluenesulfonyl]-L-Lysine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, physical characteristics, and spectroscopic data is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.