Description

n-Benzyloxycarbonyl-o-Benzoyl Aspartame is a key protected dipeptide derivative, widely utilized as a sophisticated synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile, orthogonal protection strategy for the aspartic acid and phenylalanine moieties, enabling the precise construction of complex peptide sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex peptides and peptidomimetics with therapeutic potential.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/t-Bu and Boc/Bzl strategies for the controlled incorporation of aspartic acid, preventing side reactions.
• Research & Development: Enables academic and industrial research into new peptide structures, hormone analogs, and enzyme inhibitors.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of high-value specialty chemicals and active pharmaceutical ingredients (APIs).
• Glycopeptide Synthesis: Facilitates the synthesis of glycopeptides by protecting reactive carboxyl and amine groups during glycosylation steps.
• Combinatorial Chemistry: A valuable scaffold in libraries designed for high-throughput screening in drug discovery programs.

Basic Information

Product Name	n-Benzyloxycarbonyl-o-Benzoyl Aspartame
CAS No.	5262-07-7
Molecular Formula	C26H24N2O7
Molecular Weight	476.48 g/mol
Synonyms	Z-Aspartame(Bzl)-OH; N-Cbz-O-Bzl-Aspartame; Nα-Benzyloxycarbonyl-Oβ-benzyl-L-aspartyl-L-phenylalanine methyl ester; Z-Asp(OBzl)-Phe-OMe; Cbz-Asp(OBzl)-Phe-OMe; Aspartame, N-benzyloxycarbonyl-O-benzyl-; L-Phenylalanine, N-[N-[(benzyloxy)carbonyl]-O-benzyl-L-aspartyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonyl-o-Benzoyl Aspartame is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.