Description

n-Hydroxydesipramine is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant desipramine. This compound is of significant value in research and development for its role in pharmacological studies and metabolic pathway analysis. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in neuropharmacology, drug metabolism, and pharmacokinetics (PK/PD) studies.

Application

• Pharmaceutical Intermediate: Critical synthesis component for developing and manufacturing tricyclic antidepressant analogs and related active pharmaceutical ingredients (APIs).
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical laboratories for accurate quantification of desipramine and its metabolites in biological matrices.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate the metabolic pathways, efficacy, and safety profiles of antidepressant therapies.
• Analytical Chemistry: Serves as a high-purity standard for method development and validation in techniques like HPLC, LC-MS, and GC-MS within quality control and forensic toxicology labs.
• Drug Discovery & Development: Utilized in early-stage R&D for structure-activity relationship (SAR) studies to design new central nervous system (CNS) active compounds.

Basic Information

Item	Details
Product Name	n-Hydroxydesipramine
CAS No.	5227-91-8
Molecular Formula	C18H22N2O
Molecular Weight	282.38 g/mol
Synonyms	2-Hydroxydesipramine; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol; Desipramine Hydroxy Analog; Desmethylimipramine, 2-Hydroxy-; Norimipramine, 2-Hydroxy-; 2-Hydroxy-10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
EINECS	Contact for details

Quality Control

Our n-Hydroxydesipramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by chromatographic techniques (HPLC). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.