Description

L-Glutamic Anhydride Hydrochloride is a protected derivative of the essential amino acid L-glutamic acid, serving as a crucial chiral building block in organic synthesis. This compound matters for its role in facilitating the controlled introduction of the glutamyl moiety while preventing unwanted side reactions at the carboxylic acid groups. Pharmaceutical researchers and fine chemical manufacturers need it for the synthesis of peptides, peptidomimetics, and various bioactive molecules.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of glutamate receptor modulators and neuroactive compounds.
• Peptide Synthesis: Used as a protected glutamic acid derivative in solid-phase and solution-phase peptide chemistry.
• Prodrug Development: Employed in the design of prodrugs where glutamic acid is used as a promoiety to enhance solubility or targeting.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of drugs to antibodies or polymers.
• Chemical Biology Research: Utilized in the study of glutamatergic pathways and protein-protein interactions.
• Fine Chemical Synthesis: Intermediate for creating complex molecules in agrochemical and material science research.

Basic Information

Product Name	L-Glutamic Anhydride Hydrochloride
CAS No.	5165-15-1
Molecular Formula	C5H8ClNO3
Molecular Weight	165.57 g/mol
Synonyms	L-Glutamic Acid 1,5-Anhydride Hydrochloride; (S)-3,6-Dioxopiperazine-2-carboxylic Acid Hydrochloride; L-Pyroglutamic Acid Hydrochloride; (S)-Pyroglutamic Acid Hydrochloride; 5-Oxo-L-proline Hydrochloride; PCA-HCl; L-Glutamic Acid Anhydride HCl; 5-Oxoproline Hydrochloride (L-form)
EINECS	225-923-5

Quality Control

Our L-Glutamic Anhydride Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including chiral purity verification, assay, and impurity profiling to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.