Description

H-L-Orn(Tfa)-Oh CAS NO 5123-49-9 is a protected derivative of the amino acid ornithine, where the α-amino group is protected by a trifluoroacetyl (Tfa) group. This specific protection strategy is critical for enabling selective peptide synthesis and chemical modifications in complex organic and biochemical research. It serves as a key chiral building block and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics and diagnostic agents.

Application

• Peptide Synthesis Intermediate: A crucial protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS), enabling the controlled incorporation of ornithine into peptide chains.
• Pharmaceutical Research: Used as a building block in the research and development of novel peptide drugs, antimicrobial peptides (AMPs), and targeted therapeutic agents.
• Bioconjugation Chemistry: Serves as a precursor for creating functionalized linkers and spacers in antibody-drug conjugates (ADCs) and other bioconjugation platforms.
• Biochemical Tool Development: Employed in the synthesis of enzyme substrates, inhibitors, and probes for studying biological processes and signal transduction pathways.
• Material Science: Can be utilized in the synthesis of specialized polyamides, dendrimers, and other functional polymers with tailored properties.

Basic Information

Product Name	H-L-Orn(Tfa)-Oh
CAS No.	5123-49-9
Molecular Formula	C8H11F3N2O4
Molecular Weight	256.18 g/mol
Synonyms	Nα-Trifluoroacetyl-L-ornithine; (S)-2-Amino-5-[(trifluoroacetyl)amino]pentanoic acid; L-Ornithine, N2-[(trifluoroacetyl)-]; Tfa-L-Orn-OH; N-TFA-L-ornithine; H-Orn(Tfa)-OH; Nα-TFA-L-Ornithine; (S)-5-((Trifluoroacetamido)-2-aminopentanoic acid
EINECS	Contact for details

Quality Control

Our H-L-Orn(Tfa)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.