Description

Pentafluorophenacyl Bromide is a highly reactive and versatile fluorinated organic building block. Its primary value lies in its utility as a key derivatization reagent and synthetic intermediate for introducing the pentafluorophenacyl group. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating derivatives with enhanced bioavailability or as a precursor for fluorinated compounds.
• Analytical Chemistry Reagent: Acts as a derivatizing agent for the gas chromatography (GC) or high-performance liquid chromatography (HPLC) analysis of carboxylic acids, amines, and other functional groups to improve detection.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced, fluorinated pesticides and herbicides, where fluorine atoms can increase biological activity and stability.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials that incorporate pentafluorophenyl groups for specific electronic or physical properties.
• Peptide & Protein Modification: Used for selective labeling or modification of biomolecules in biochemical research and diagnostic assay development.
• Cross-coupling Reactions: Functions as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures common in modern organic synthesis.

Basic Information

Product Name	Pentafluorophenacyl Bromide
CAS No.	5122-16-7
Molecular Formula	C8H2BrF5O
Molecular Weight	288.99 g/mol
Synonyms	2-Bromo-1-(2,3,4,5,6-pentafluorophenyl)ethanone; α-Bromopentafluoroacetophenone; Pentafluoro-ω-bromoacetophenone; Pentafluorophenacyl bromide; 2-Bromo-2',3',4',5',6'-pentafluoroacetophenone; 1-(Pentafluorophenyl)-2-bromoethanone; PFB-Br; ω-Bromo-2,3,4,5,6-pentafluoroacetophenone
EINECS	225-865-5

Quality Control

Our Pentafluorophenacyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.