Description

2,4,5-Trifluoroanisole is a versatile fluorinated aromatic ether, a key building block in advanced organic synthesis. Its value lies in its trifluoromethyl-substituted anisole structure, which imparts unique electronic and steric properties critical for modifying the biological activity and physical characteristics of target molecules. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and liquid crystal materials industries seeking to introduce fluorine motifs for enhanced product performance.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in constructing fluorinated aromatic cores for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a key precursor in manufacturing advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity, metabolic stability, and overall efficacy.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystal compounds for high-performance displays (LCDs), where it helps fine-tune dielectric anisotropy and viscosity.
• Organic Electronics: Acts as a building block for electron-transport materials, semiconductors, and other components in OLEDs and organic photovoltaics due to its electron-withdrawing character.
• Chemical Research & Development: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, value-added fluorinated compounds for various applications.

Basic Information

Product Name	2,4,5-Trifluoroanisole
CAS No.	5006-38-2
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	1,2,4-Trifluoro-5-methoxybenzene; Methoxy-2,4,5-trifluorobenzene; 2,4,5-Trifluoromethoxybenzene; 2,4,5-Trifluorophenyl methyl ether; Anisole, 2,4,5-trifluoro-; Benzene, 1,2,4-trifluoro-5-methoxy-; NSC 406914
EINECS	225-673-4

Quality Control

Our 2,4,5-Trifluoroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for fine chemical and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for review and provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.