Description

tert-Butyllithium is a highly reactive organolithium compound, widely recognized as a powerful base and nucleophile in synthetic organic chemistry. Its value lies in its exceptional ability to perform efficient and selective deprotonations and lithium-halogen exchange reactions, enabling the construction of complex molecular frameworks. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used for the synthesis of active pharmaceutical ingredients (APIs), specialty chemicals, and novel polymers.

Application

• As a strong base for the deprotonation of weak carbon acids to generate reactive carbanions.
• In lithium-halogen exchange reactions for the preparation of functionalized organolithium intermediates.
• Key reagent in the synthesis of pharmaceutical intermediates and active ingredients, particularly for steroid and alkaloid frameworks.
• Initiation of anionic polymerization processes for producing block copolymers and elastomers with precise molecular weights.
• Used in metallation reactions for directing group-assisted functionalization of aromatic compounds.
• Preparation of specialty organometallic reagents used in cross-coupling and other transition metal-catalyzed reactions.
• As a reducing agent in specific organic transformations.

Basic Information

Product Name	tert-Butyllithium
CAS No.	594-19-4
Molecular Formula	C4H9Li
Molecular Weight	64.06 g/mol
Synonyms	t-Butyllithium; Lithium tert-butyl; Lithium tert-butoxide (incorrect but common); t-BuLi; 2-Methyl-2-propyllithium; tert-C4H9Li; Lithium tri-methylmethanide; Lithium (1,1-dimethylethyl)-
EINECS	209-831-5

Quality Control

Our tert-Butyllithium is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. The product undergoes rigorous analytical testing, including titration for precise assay determination and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, concentration (typically in hydrocarbon solutions like pentane or hexane), and critical parameters is provided with each shipment to support your quality assurance and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its pyrophoric and moisture-sensitive nature, it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area, away from heat, sparks, and open flames. For solutions, store at 2-8°C or as specified on the label. Keep away from oxidizing agents, acids, and water.

Specification

Item	Specification
Appearance (Solution)	Colorless to pale yellow liquid
Assay (by Titration)	1.0-1.7 M in hydrocarbon solvent (e.g., pentane)
Purity (GC)	≥ 95% (relative area)
Identification (IR)	Conforms to structure
Water (Karl Fischer)	≤ 0.1% w/w
Acidity (by Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.