Description

Phenyllithium is a highly reactive organolithium compound, widely recognized as a powerful nucleophile and base in synthetic organic chemistry. Its primary value lies in its ability to efficiently introduce a phenyl group into target molecules, making it indispensable for constructing complex aromatic frameworks. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used for key carbon-carbon bond-forming reactions such as lithium-halogen exchange and nucleophilic additions.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing aryl-aryl bonds and introducing phenyl groups into active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the synthesis of herbicides, fungicides, and other crop protection agents that contain aromatic ring systems.
• Polymer & Material Science: Employed as an initiator or modifying agent in the production of specialty polymers and advanced organic electronic materials.
• Fine Chemical Manufacturing: Facilitates the synthesis of complex ligands, dyes, and fragrances through efficient phenyl-lithiation reactions.
• Lithium-Halogen Exchange Reactions: A standard reagent for generating other organolithium species from aryl halides, enabling further functionalization.
• Nucleophilic Addition to Carbonyls: Used for the addition of phenyl anions to aldehydes, ketones, and esters to form secondary and tertiary alcohols.

Basic Information

Product Name	Phenyllithium
CAS No.	591-51-5
Molecular Formula	C6H5Li
Molecular Weight	84.05 g/mol
Synonyms	Lithium phenyl; Benzenelithium; Phenyllithium solution; Phenyl lithium; Lithium benzenide; LiPh; PhLi
EINECS	209-718-6

Quality Control

Our Phenyllithium is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration for precise assay determination and impurity profiling, to ensure consistency and high reactivity. Certificates of Analysis (COA) detailing purity, concentration (typically in common solvents like diethyl ether or cyclohexane), and other critical parameters are provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area. For solutions, refer to the specific solvent's flash point and storage recommendations. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow
Assay (by Titration)	1.0 - 2.0 M in specified solvent (e.g., diethyl ether)
Purity (GC)	≥ 95% (relative area)
Identity (IR / NMR)	Conforms to structure
Residue after Evaporation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.