Description

4,4,4-Trifluorocrotonamide is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the trifluoromethyl group and the amide functionality, enabling the construction of complex molecules with tailored properties. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, potentially enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, insecticides, and fungicides where the fluorine atoms can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated polymers or specialty chemicals with unique surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyclizations, and as a source of the -CF3 moiety in medicinal chemistry.
• Ligand and Catalyst Development: Potential use in designing novel ligands for catalysis in asymmetric synthesis.

Basic Information

Product Name	4,4,4-Trifluorocrotonamide
CAS No.	590-76-1
Molecular Formula	C4H4F3NO
Molecular Weight	139.08 g/mol
Synonyms	4,4,4-Trifluorobut-2-enamide; (E)-4,4,4-Trifluorocrotonamide; 4,4,4-Trifluoro-2-butenamide; 2-Butenamide, 4,4,4-trifluoro-; 4,4,4-Trifluorocrotonic acid amide; trans-4,4,4-Trifluorocrotonamide; 590-76-1; NSC 406071
EINECS	209-694-5

Quality Control

Our 4,4,4-Trifluorocrotonamide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics is provided with every shipment to guarantee it meets your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.