Description

1,2,3-Tribromo-5-Fluorobenzene is a halogenated aromatic compound of significant interest in advanced organic synthesis. Its unique structure, featuring three bromine atoms and one fluorine atom on the benzene ring, makes it a versatile and valuable building block for creating complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a critical intermediate for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the tribromo-fluorobenzene moiety imparts specific biological activity.
• Material Science Research: Serves as a monomer or building block for the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Reference Standard: Employed in analytical laboratories as a standard for method development and quality control testing of related compounds.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of multiple bromine atoms, enabling sequential functionalization.
• Fluorine Chemistry Studies: Used in research exploring the effects of fluorine substitution on the reactivity and physical properties of polyhalogenated benzenes.

Basic Information

Item	Detail
Product Name	1,2,3-Tribromo-5-Fluorobenzene
CAS No.	576-82-9
Molecular Formula	C6H2Br3F
Molecular Weight	332.79 g/mol
Synonyms	5-Fluoro-1,2,3-tribromobenzene; 1,2,3-Tribromo-5-fluorobenzene; 2,3,4-Tribromofluorobenzene; Tribromofluorobenzene; F-Br3-Benzene (abbrev.); Benzene, 1,2,3-tribromo-5-fluoro-; NSC 37736
EINECS	209-401-5

Quality Control

Our 1,2,3-Tribromo-5-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and GC-MS, NMR, and IR for identity confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	72 - 76 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.