Description

Met-Lys-Bradykinin CAS NO 550-19-6 is a synthetic peptide analog of the endogenous vasoactive nonapeptide bradykinin, modified with a methionine and lysine substitution. This modification can enhance stability and alter receptor binding affinity, making it a valuable tool for pharmacological research and biochemical studies. It is primarily utilized by research institutions and pharmaceutical companies investigating cardiovascular physiology, inflammation pathways, and pain mechanisms.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of the kinin-kallikrein system, G-protein coupled receptor (GPCR) signaling, and vascular permeability.
• Biochemical Assay Development: Serves as a critical substrate or ligand in the development of enzyme activity assays (e.g., for angiotensin-converting enzyme) and receptor binding assays.
• Inflammation and Pain Studies: Applied in vitro and in vivo models to study the role of bradykinin in inflammatory responses, neurogenic pain, and edema.
• Cardiovascular Research: Investigated for its effects on blood pressure regulation, smooth muscle contraction, and endothelial function.
• Peptide Chemistry & Drug Discovery: Used as a building block or model compound for designing novel peptide-based therapeutics with improved metabolic stability.
• Diagnostic Kit Manufacturing: May be incorporated as a calibrated component in diagnostic kits targeting biomarkers related to the kinin system.

Basic Information

Product Name	Met-Lys-Bradykinin
CAS No.	550-19-6
Molecular Formula	C58H89N17O13S
Molecular Weight	1240.5 g/mol
Synonyms	Methionyl-lysyl-bradykinin; MK-Bradykinin; [Met0, Lys1]-Bradykinin; Bradykinin, N2-[(1S)-1-carboxy-3-(methylthio)propyl]-N5-(5-amino-1-carboxypentyl)-L-lysyl-L-arginyl-L-prolyl-L-prolyl-L-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine; H-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
EINECS	Contact for details

Quality Control

Our Met-Lys-Bradykinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.