Description

Bretylium CAS NO 59-41-6 is a quaternary ammonium salt and adrenergic neuron-blocking agent of significant pharmaceutical importance. It is primarily valued for its antiarrhythmic properties, specifically in the management of life-threatening ventricular arrhythmias. This compound is a critical active pharmaceutical ingredient (API) and research chemical for manufacturers and R&D laboratories in the global pharmaceutical and life sciences sectors.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key component in the formulation of antiarrhythmic medications.
• Cardiovascular Research: A vital tool in preclinical and clinical studies investigating ventricular tachycardia and fibrillation.
• Pharmacological Studies: Used to study adrenergic neurotransmission, neuron-blocking mechanisms, and cardiac electrophysiology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.
• Chemical Synthesis Intermediate: Utilized in the research-scale synthesis of novel chemical entities and analogs for drug discovery programs.

Basic Information

Product Name	Bretylium
CAS No.	59-41-6
Molecular Formula	C18H24BrNO3S
Molecular Weight	414.36 g/mol
Synonyms	Bretylium Tosylate; Bretylium Tosilate; Bretylan; Bretylium p-Toluenesulfonate; N-(2-Bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate; Darenthin; Ornid; 4-Methylbenzenesulfonic acid compd. with N-(2-bromobenzyl)-N,N-dimethylethanaminium (1:1)
EINECS	200-418-7

Quality Control

Our Bretylium is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. It is suitable for pharmaceutical R&D and reference standard applications. Comprehensive testing is performed, including identity confirmation, assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each batch, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.